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Wiley Laboratory Exercises in Microbiology 2021 Edition by Robert A. Pollack , Lorraine Findlay
Table of Contents : Preface ixList of Abbreviations xi1 The History of ZIKV Discovery 11.1 ZIKV Isolation from Monkeys and Mosquitos 11.2 ZIKV Infection in Humans 61.3 ZIKV Infection Spread to Other Hosts and Regions 71.4 Cross?Paths between ZIKV and Other Flaviviruses 9References 102 ZIKV: From Silent to Epidemic 152.1 Outbreak in Yap Island (2007) 152.2 Outbreak in French Polynesia (2013) 162.3 How Did ZIKV Reach Brazil? 182.4 Outbreak in Brazil (2015) 182.5 ZIKV Spread through South, Central, and North Americas 20References 223 ZIKV Transmission and Prevention 293.1 Modes of Transmission 293.2 Prevention 37References 404 Association with Guillain?Barre Syndrome and Microcephaly 494.1 Association with Neurological Disorders 49References 585 ZIKV Animal Models 695.1 Animal Models: Embryonated Hen Eggs 695.2 Animal Models: Landrace Piglet 695.3 Animal Models: Mice 705.4 Animal Model: Nonhuman Primate 74References 786 Biology of ZIKV 836.1 Structural and Physical Properties of ZIKV Virion 846.2 Binding and Entry 876.3 Genome Structure 896.4 Translation and Proteolytic Processing 916.5 Features of the Nonstructural Proteins 926.6 RNA Replication 1006.7 Features of the Structural Proteins 1046.8 Virus Assembly and Release from Virus?Infected Cells 107References 1097 Zika Virus (ZIKV) Strains and Lineages 1317.1 East and West African Lineage 1317.2 Africa vs. Asian/American Lineage 132References 1408 ZIKV?Host Interactions 1478.1 Systematic Studies to Identify ZIKV Affected Functions and Pathways 1478.2 Induction and Dysregulation of Innate Immune Responses during ZIKV Infection 1508.3 Induction of Cell Death and Apoptosis by ZIKV 1568.4 Induction of Autophagy by ZIKV 1608.5 Dysregulation of Cell Cycle and Induction of Abnormal Mitosis by ZIKV 163References 1649 Inhibitors of ZIKV Replication and Infection 1799.1 Drugs That Lead to the Destruction of ZIKV Virions 1799.2 Drugs That Inhibit ZIKV Entry and Endocytosis 1809.3 Drugs That Target ZIKV NS2B?NS3 Protease Activity 1869.4 Drugs That Target ZIKV NS5 RNA?Dependent RNA Polymerase Activity 1919.5 Neutralizing Antibodies That Target ZIKV Structural Protein 2009.6 Drugs That Inhibit ZIKV Infection by Targeting Host Machinery 2019.7 Drugs That Show Neuroprotective Activity but Do Not Suppress ZIKV Replication: Emricasan 2059.8 Other Drugs That Inhibit ZIKV Infection Identified from a Screening of FDA?Approved Drugs 206References 21010 Long?Term Care and Perspectives 22910.1 Prenatal Care and Diagnosis of Abnormal Fetus Development 22910.2 Long?Term Care for Patients Affected by ZIKV 23010.3 Assistance to Families with Children Affected by ZIKV 23010.4 Perspectives 231References 232Index 237