Description
LAP Lambert Academic Publishing Lipidnye I Nelipidnye Effekty Atorvastatina 2012 Edition by Yalymov Anatoliy
Nauchnaya rabota posvyashchena izucheniyu vliyaniya ingibitora GMG-KoA-reduktazy atorvastatina v sostave kompleksnoy terapii bol'nykh s ostrym koronarnym sindromom (OKS). Otsenivalos' vliyanie atorvastatina na kachestvo zhizni patsientov s OKS, klinicheskoe techenie i iskhody zabolevaniya, osnovnye parametry tsentral'noy i perifericheskoy gemodinamiki, elektricheskuyu nestabil'nost' miokarda. Izuchalas' dinamika pokazateley lipidnogo spektra krovi, parametrov gemoreologii, trombotsitarnogo i koagulyatsionnogo gemostaza, stepeni disfunktsii endoteliya i faktorov vospaleniya na razlichnykh etapakh zabolevaniya. Vklyuchenie atorvastatina v sostav kompleksnoy terapii OKS, normalizuet narushennye pokazateli lipidnogo obmena, blagopriyatno vliyaet na pokazateli tsentral'nogo gemodinamiki, umen'shaet priznaki elektricheskoy nestabil'nosti miokarda, korregiruet endotelial'nuyu disfunktsiyu. Dlitel'nyy priem atorvastatina sposobstvuet dostovernomu snizheniyu urovnya S-reaktivnogo belka i faktora Villebranda, chto svidetel'stvuet ob umen'shenii vnutrisosudistogo vospaleniya i stepeni endotelial'noy disfunktsii.