Description
Taylor & Francis Molecular Diagnosis and Treatment of Melanoma 1998 Edition by John M. Kirkwood
Facilitating efforts to prevent melanoma progression, this up-to-date reference presents the most recent advances in the pathology, molecular biology, and therapy of melanoma in early, high-risk, and advanced stages. Discusses growth factors, cytokines, receptors, oncogenes, tumor suppressor genes, adhesion molecules, and proteases in melanoma and examines the appropriate use of interferon adjuvant therapy! Written by leading authorities from the United States and Europe, Molecular Diagnosis and Treatment of Melanomadetails the preclinical and clinical basis for new vaccines based on gangliosides and peptides explains the roles of chemotherapy and radiosurgery reviews the molecular features of melanoma and precursor cells describes the events involved in induction and maintenance of antitumor T-cell response and various escape mechanisms from immune recognition analyzes melanotic and dysplastic nevi explores the potential of vaccines that induce antibodies in immunotherapy and vaccines in high-risk melanoma summarizes cytotoxic chemotherapy in treating metastatic melanoma elucidates whole-brain radiotherapy, surgical resection, and stereotactic radiosurgery in managing melanoma brain metastasis and more! Containing key bibliographic citations for more in-depth study of particular topics, Molecular Diagnosis and Treatment of Melanoma is an excellent resource for oncologists, dermatologists, molecular and cell biologists, immunologists, pathologists, pharmacologists, toxicologists, interns, residents, fellows, and graduate and medical school students in these disciplines. Table of contents : - Molecular Features of the Biology of Melanoma Molecular Features of Melanoma Progression, Ulrich Rodeck and Dorothea BeckerImmunologic Features of Progression in Melanoma, Jurgen C. Becker and Eva-Bettina Broecker The Precursor Lesion in Melanoma: Propspects for Prevention Common Acquired Nevi and Dysplastic Nevi as Precursor Lesions and Risk Markers of Melanoma, John T. Seykora and David E. ElderAdjuvant Therapy of Resected Cutaneous High-Risk Melanoma Lymphatic Mapping and Sentinel Lymph Node Biopsy in the Care of the Patient with Melanoma, Douglas S. Reintgen and Andrea BrobeilMolecular Approaches to Adjuvant Immunological Therapy of Melanoma with Interferon (IFN): The Role of Interferons and Other Cytokines as an Adjunct to Surgery in Intermediate- and High-Risk Melanoma, John M. KirkwoodThe Case for Melanoma Vaccines that Induce Antibodies, Philip O. LivingstonVaccine Trials in High-Risk Melanoma: Induction of Effector T-Cell Responses to Melanoma, Walter J. Storkus, John M. Kirkwood, and Thomas TutingAdjuvant Chemotherapy for Malignant Melanoma, Agop Y. Bedikian and Sewa Singh LeghaTherapy of Advanced Metastatic Melanoma The Role of Cytotoxic Chemotherapeutic Agents Either Alone or in Combination with Biological Response Modifiers, Michael B. AtkinsRadiosurgery in the Management of Melanoma Brain Metastasis, John C. Flickinger, Salvador Somaza, and Douglas KondziolkaPCR-Based Detection of Malignant Cells: Toward Molecular Staging?, Ulrich Keilholz and Martina Willhauck