Description
LAP LAMBERT Academic Publishing Monitoring Lekarstvennoy Terapii Bronkhialnoy Astmy U Detey 2011 Edition by Kirilochev Oleg, Umerova Adelya
Bronkhial'naya astma - odno iz samykh rasprostranyennykh allergicheskikh zabolevaniy u detey. Razrabotka kriteriev effektivnosti i bezopasnosti lekarstvennoy terapii bronkhial'noy astmy yavlyaetsya aktual'nym napravleniem v meditsine. Dlya monitoringa farmakoterapii provodilos' izuchenie sostoyaniya sistemy mikrotsirkulyatsii i soderzhanie glutationa v tsel'noy krovi. Udalos' vyyavit' kliniko-diagnosticheskie osobennosti i vozmozhnosti kontrolya lekarstvennoy terapii bronkhial'noy astmy v zavisimosti ot stepeni tyazhesti. Pri lyegkoy stepeni zabolevaniya sindrom bronkhial'noy obstruktsii obuslavlival so storony sistemy mikrotsirkulyatsii kompensatornye sdvigi modulyatsii sosudistogo tonusa, napravlennye na uluchshenie perfuzii tkaney. Pri sredney stepeni tyazhesti vyrazhennost' sindroma bronkhoobstruktsii ne pozvolyala sisteme mikrotsirkulyatsii kompensirovat' patologiyu. Bronkhial'naya astma tyazhyeloy stepeni vyzyvala sryv mekhanizmov adaptatsii, v tom chisle na fone farmakoterapii. Nablyudalos' otsutstvie polozhitel'noy dinamiki posle provedyennoy farmakoterapii. Snizhenie vosstanovlennogo glutationa pri lechenii persistiruyushchey bronkhial'noy astmy sredney i tyazhyeloy stepeni svidetel'stvovalo o narushenii vnutripechyenochnogo metabolizma.