Description
Humana Press Monoclonal Antibodies in Cancer 1st Editon 2011 Softbound by Stewart Sell, Ralph Reisfeld
1 Monoclonal Antibody Defined Antigens on Animal Tumors.- 1. Introduction.- 2. Antigen Expression on Chemically Induced Tumors.- 2.1. Murine Tumors.- 2.2. Rat Tumors.- 2.3. Guinea Pig Tumors.- 3. Use of Monoclonal Antibodies in Tumor Localization and Therapy.- 3.1. In Vivo Localization of Monoclonal Antibodies in Experimental Tumors.- 3.2. Serotherapy Using Antitumor Monoclonal Antibodies.- 3.3. Therapy Using Antitumor Monoclonal Antibodies Conjugated to Cytotoxic Agents.- 4. Conclusion.- References.- 2 Monoclonal Carcinoembryonic Antigen Antibodies.- 1. Introduction.- 2. The Development of Monoclonal CEA Immunoassays.- 2.1. General Concepts of Monoclonal Antibody Methodology.- 2.2. Experimental and Clinical Experience with Monoclonal CEA Antibodies.- 3. Monoclonal Antibodies in the Immunohistological Evaluation of CEA.- 4. Monoclonal Anti-CEA Antibodies in Tumor Imaging.- 5. Immunotherapy with Monoclonal CEA Antibodies.- 6. Summary.- References.- 3 Monoclonal Antibodies to Alphafetoprotein and Regulation of AFP Gene Expression.- 1. Introduction.- 2. Monoclonal Antibodies to AFP.- 2.1. ELISA Using Monoclonal Antibodies.- 2.2. Immune Localization Using Anti-AFP.- 2.3. Radioimmunescintigraphy.- 2.4. Immunotherapy.- 3. Control of AFP Gene Expression.- 3.1. AFP and Albumin Gene Expression During Development.- 3.2. AFP and Albumin Gene Structure.- 3.3. AFP and Albumin Gene Expression and Methylation.- 4. Summary.- References.- 4 Human Chorionic Gonadotropin Detection with Monoclonal Antibodies.- 1. Introduction: hCG Chemistry and Immunochemistry with Antisera.- 2. Description of Monoclonal Antibodies to hCG.- 2.1. Affinity, Isotype, Subclass, and Cross-Reactivity of Antibodies.- 2.2. Topological Mapping of Monoclonal Antibodies: Relative Orientation of Epitopes.- 2.3. Biological Effects of Monoclonal Antibodies Against hCG.- 2.4. Special Properties of Monoclonal Antibodies to hCG: Synergistic Effects.- 3. Immunoassays with Monoclonal Antibodies to hCG.- 3.1. Description of Commercial Immunoassays for hCG Employing Monoclonal Antibodies.- 3.2. Research Immunoassays for hCG.- 4. In Vivo Immunodetection of Tumors.- 5. Immunocytochemistry with Monoclonal Antibodies to hCG.- 6. Summary.- References.- 5 Products of the Major Histocompatibility Complex on Tumor Cells.- 1. Introduction.- 2. Variable Expression of MHC Antigens by Tumor Cells.- 2.1. Inducible MHC Antigens on Murine Tumors Cells.- 2.2. Inducible MHC Antigens on Human Tumors.- 2.3. Implications for Human Tumor Immunology.- 3. Abnormal Expression of MHC Antigens by Tumor Cells.- 3.1. Abnormal Expression of MHC Antigens on Murine Tumor Cells.- 3.2. Abnormal Expression of MHC Antigens on Human Tumor Cells.- 4. Conclusions.- References.- 6 Monoclonal Antibodies: Probes for the Study of Malignant T Cells.- 1. Introduction.- 2. Monoclonal Antibodies as Probes for the Study of Malignant T Cells.- 3. Normal T-Cell Maturation as Defined by Monoclonal Antibodies.- 4. Phenotypic Analysis of Malignant T Cells in Defined Clinical Syndromes.- 4.1. T-Cell Acute Lymphoblastic Leukemia.- 4.2. T-Cell Lymphoblastic Lymphoma.- 4.3. T-Cell Prolymphocytic Leukemia.- 4.4. Cutaneous T-Cell Lymphoma.- 4.5. T-Cell Chronic Lymphocytic Leukemia.- 4.6. IgG Fc Receptor Beraing (TG) Lymphoproliferative Disease.- 4.7. Hairy Cell Leukemia.- 4.8. HTLV-Associated Japanese, Caribbean, and American Adult T-Cell Leukemia/Lymphoma (ATL).- 4.9. Diffuse Lymphomas.- 4.10. T-Cell “Premalignant” Proliferative Disease.- 4.11. Thymoma.- 5. Summary and Conclusions.- References.- 7 Antigenic Markers on Normal and Malignant B Cells.- 1. Introduction.- 2. Antigenic Markers on Normal B Cells.- 3. Antigenic Markers on Malignant B Cells.- Bibliography for Further Reading.- 8 Nonlymphoblastic Leukemia-Associated Antigens Identified by Monoclonal Antibodies.- 1. Introduction.- 2. Myeloid-Associated Antigens Expressed by Normal Hemat