Description
Plenum Publishing Corporation Nephrotoxic Mechanisms Of Drugs And Environmental Toxins 1982 Edition by George A Porter
The majority of the offending toxicants to be reviewed in this volume were devel oped to help mankind, and it is only with prolonged or widespread application that their adverse effects have been recognized. Conversely, in the case of pre scrip tion drugs, there has been an attempt to identify the adverse effects in advance and incorporate these risks into the decision of approval for human consumption. Unfortunately, for those drugs in which recognized injury occurs only after prolonged use, such appraisals are made in retrospect. Despite this, most renal injury induced by drugs or toxicants can be either prevented by excluding drugs with unacceptable side effects or interrupted by eliminating the offending agent once damage is manifested. The fact that prevention, reversibility, or arrest of renal injury is possible provided a major impetus for this publication. Since no international registry for nephrotoxic injury exists, estimates of incidence must rely on less than ideal sources. Recently I, together with Dr. William Bennett, summarized a survey of the frequency of various categories of nephrologic disease (Porter and Bennett, 1981). Based on this survey, we projected that in nearly one of ten patients seeking nephrologic consultation a nephrotoxic etiology may be involved. Of cases of end-stage renal disease, between 3 and 4% are due to drug nephrotoxicity, according to recent published results(European Dialysis and Transplant Association, 1979). For acute renal failure, antibiotics and contrast agents persist as major offending agents, while for chronic renal failure, analgesics remain a worldwide problem. Table of contents : The Nature of Fragmentation; L.K. Marsh. Section I: Genetics and Population Dynamics; L.K. Marsh.Effects of Habitat Fragmentation on the Genetic Variability of Silvery Marmosets, Mico Argentatus; E.C. Goncalves, et al. Changes in Distribution of the Snub-Nosed Monkey in China. B. Li, et al. Analyses of the Hypothetical Population Structure of the Squirrel Monkey (Saimiri Oerstedii) in Panama; A.R. Rodriguez-Vargas. Primate Survival in Community-Owned Forest Fragments: Are Metapopulation Models Useful amidst Intensive Use? C.A. Chapman, et al. Relationships between Forest Fragments and Howler Monkeys (Alouatta Palliata Mexicana) in Southern Veracruz, Mexico; E.M. Rodriguez-Toledo, et al. Primates of the Brazilian Atlantic Forest: The Influence of Forest Fragmentation on Survival; A.G. Chiarello. Dynamics of Primate Communities along the Santarem-Cuiaba Highway in South-Central Brazilian Amazonia; S.F. Ferrari, et al. Primates and Fragmentation of the Amazon Forest; K.A. Gilbert. Section II: Behavorial Ecology; L.K. Marsh. Impacts of Forest Fragmentation on Lion-Tailed Macaque and Nilgiri Langur in Western Ghats, South India; G. Umapathy, et al. Population Size and Habitat Use of Spider Monkeys at Punta Laguna, Mexico; G. Ramos-Fernandez, et al. Changes in Forest Composition and Potential Feeding Tree Availability on a Small Land-Bridge Island in Lago Guri, Venezuela; M.A. Norconk, et al. Foraging Strategy Changes in an Alouatta Palliata Mexicana Troop Released on an Island; E. Rodriguez-Luna, et al. Dietary Flexibility, Behavioral Plasticity, and Survival in Fragments: Lessons from Translocated Howlers; S.C. Silver, et al. Howler Monkeys (Alouatta Pallicata Mexicana) as Seed Dispensers of StranglerFigs in Disturbed and Preserved Habitat in Southern Veracruz, Meexico; J.C. Serio-Silva, et al. How Do Howler Monkeys Cope with Habitat Fragmentation? J.C. Bicca-Marques. Section III: Conservation and Management; L.K. Marsh.Fragments, Sugar, and Chimpanzees in Masindi District, Western Uganda; V. Reynolds, et al. Shade Coffee Plantations as Wildlife Refuge for Mantled Howler Monkeys (Alouatta Palliata) In Nicaragua; C. McCann, et al. Effects of Habitat Fragmentation on the Cross River Gorilla (Gorilla Gorilla Diehli): Recommendations for Conservation; E.A. Eniang. Wild Zoos: Conservation of Primates in Situ; L.K. Marsh.Section IV: Integration and Future Directions.Fragmentation: Specter of the Future or the Spirit of Conservation; L.K. Marsh, et al. Suggested Reading. Index.