Description
Springer New Aspects in Hypertension Adrenoceptors Symposium November 1985 Munich 1st Editon 2011 Softbound by M. Middeke, H. Holzgreve
This book reports on the current state of knowledge about adreno ceptors and their involvement in the pathogenesis and treatment of high blood pressure. This is a relatively recent and extremely excit ing addition to the field of hypertension research. The development of new analytical procedures, such as radio ligand-binding methods, has made it possible to identify and quantify the adrenoceptors in different tissues and in circulating blood cells. As a consequence, much new and valuable information has been obtained. An under standing of the role of the fJ-adrenoceptor-adenylatecyclase-cAMP system in hypertension is one such product of this new approach. Both review articles and new experimental and clinical data are included in this volume. New aspects of the distribution, identifica tion and regulation, and the chronopharmacology of adrenoceptors, as well as beta blockade, will be highlighted. The clinical contributions concern the normal regulation of the fJ adrenoceptor-adenylatecyclase-cAMP system, and how it is altered in hypertensives as a possible mechanism in the pathogenesis and maintenance of essential hypertension. With this knowledge it is be coming easier to explain the molecular and cellular action behind the familiar role of the sympathico-adrenergic system in the devel opment of hypertension and the mechanism of beta blockade. The vast majority of the data available in this field is confined to periph eral mechanisms, owing to the limited possibilities for investigating the central nervous system under clinical conditions. Central Nervous Noradrenergic and Adrenergic Systems and their Functions.- Peripheral Sympathoadrenal System: Transmitter Release and Distribution of Adrenoceptors.- Characterization of Adrenoceptors: Receptor Binding Studies and Agonist-Antagonist Interaction.- Agonist Interaction with ?2-Adrenoceptors of Human Platelets.- Regulation of the ?-Adrenergic Receptor - Adenylate Cyclase System in Cardiac Membranes.- Frequency Regulation in the Sino-Atrial Node: Function of ?1 and ?2 -Receptors.- Mechanisms of Stimulatory and Inhibitory Coupling to Adenylate Cyclase.- Aspects of the Pathogenesis of Essential Hypertension.- Sympathetic Nervous System in Essential Hypertension: Activity and Reactivity.- Adrenoceptors in Hypertension.- Adrenoceptor Alterations in Different Tissues in Human and Animal Genetic Hypertension.- Alpha2 Adrenoceptor-Mediated Alteration of Contractile Systems.- Beta Adrenoceptor Changes in Hypertension Induced by Dynamic Exercise.- Effect of Fludrocortisone on Adrenoceptors and Free Intracellular Calcium in Man.- Daily Variations in the Beta-Adrenoceptor-Adenylate-Cyclase- cAMP-Phosphodiesterase System.- Hypotensive Effect of ?-Adrenoceptor Blockers.- Effects of Antihypertensive Agents on Alpha and Beta Adrenoceptors.- Mode of Action of Beta Blockers in Hypertension.