Description
Springer PET and SPECT of Neurobiological Systems 2021 Edition by Rudi A.J.O. Dierckx, Andreas Otte, Erik F.J. de Vries, Aren van Waarde, Adriaan A. Lammertsma
This book, now in a fully updated second edition, is a comprehensive and up-to-date guide to the use of PET and SPECT for the imaging of neurobiological systems. Diverse aspects of neurotransmission in the brain are discussed, such as visualization and quantification of neuroreceptors, neuroinflammatory markers, transporters, and enzymes as well as neurotransmitter synthesis, -amyloid deposition, cerebral blood flow, and the metabolic rate of glucose. The latest results in probe development are also detailed. A wide range of systems not addressed in the first edition are covered, reflecting the advances made in recent years. The book combines the expertise of authors internationally renowned for their dedication to the development of novel probes and techniques for the investigation of neurobiological systems. Most chapters are written jointly by radiochemists and nuclear medicine specialists to ensure a multidisciplinary approach. This state of the art compendium will be valuable to all with an interest in clinical and preclinical neuroscience. Companion volumes on the use of PET and SPECT in neurology and psychiatry complete a trilogy. Table of contents: PARTI : BASICS1. Animal Models for Brain Research (Debby van Dam, Antwerpen)2. Small Animal Molecular Imaging - PET, SPECT (Steven Staelens, Antwerpen)3. Cerebral Glucose Metabolism (W.Dieter Heiss, Koeln)4. Cerebral Blood Flow Measurement with 15O-Water PET (Henryk Barthel, Leipzig)5. Principles of Brain Perfusion SPECT (Shana Elman, Albuquerque)6. The Impact of Genetic Polymorphisms on Neuroreceptor Imaging (Matthaus Willeit, Wien)PART II: SYSTEMS7. Acetylcholinesterase [Hitoshi Shinotoh, Chiba]8. Adenosine Receptors {David Elmenhorst, Julich]9. Beta-Amyloid and Other Proteinopathies [Agneta Nordberg, Stockholm]10. Central Benzodiazepine Receptors [Hiroshi Yamauchi, Shiga]11. Cyclooxygenase-2 [Frank Wuest, Edmonton]12. Dopamine System in Humans [Jan Booij, Amsterdam]13. Endocannabinoid System [Andrew G. Horti, Baltimore]14. Glutamate Receptors (Metabotropic) [Simon M. Ametamey, Zurich]15. Histamine H3 Receptors [Makiko Yamada, Chiba]16. Hormone Receptors (Steroids) [Erik F.J. de Vries, Groningen]17. Monoamine Oxidase B [Elena Rodriguez-Vieitez, Stockholm]18. MRP1 Function in the BBB [Toshimitsu Okamura, Chiba]19. Neuroinflammation: From Target Selection to Preclinical and Clinical Studies [Andreas Jacobs,Munster]20. Nicotinic Acetylcholine Receptors [Peter Brust, Leipzig]21. NMDA Receptors [Yasuhiro Magata, Hamamatsu]22. Norepinephrine Transporter [Yu-Shin Ding, New York]23. Opioid Receptors [Aren van Waarde, Groningen ?]24. P-Glycoprotein and Other ABC Transporters [Gert Luurtsema, Groningen]25. Phosphodiesterases [Guy Bormans, Leuven]26. Purinergic Receptors [Bieneke Janssen, Philadelphia]27. Serotonin System [Steen G. Hasselbalch, Copenhagen]28. Serotonin Transporter and Monoamine Oxidase A [Jeffrey H. Meyer, Toronto]29. Sigma-1 Receptors [Frederick T Chin, Stanford]30. Sigma-2 Receptors [Robert H Mach, Philadelphia]31. Synaptic Density (SV2A) [Sjoerd Finnema, New Haven]32. Tau Pathology [Victor H Villemagne, Melbourne]33. Translocator Protein [David J. Brooks, Aarhus]34. Tropomyosin Receptor Kinase [Ralf Schirrmacher, Edmonton]35. Vesicular Acetylcholine Transporter (Barbara Wenzel, Dresden-Rossendorf]36. Vesicular Monoamine Transporter [Michael R. Kilbourn, Ann Arbor]