Pharmaceutical Dosage Forms And Drug Delivery by Ram I. Mahato , Taylor & Francis Ltd

Description

Taylor & Francis Ltd Pharmaceutical Dosage Forms And Drug Delivery by Ram I. Mahato

Integrating aspects of physical pharmacy, biopharmaceuticals, drug delivery, and biotechnology, Pharmaceutical Dosage Forms and Drug Delivery elucidates basic physicochemical principles and their application in the design of dosage forms. The author addresses the relevance of these principles to the biopharmaceutical aspects of drugs. He explores the latest developments in the application of biomaterials, including polymers and biotechnology-based agents, to the development of novel dosage forms. _x000D_The book covers physicochemical principles of dosage design, biopharmaceutical and physiological considerations, types of commonly used pharmaceutical dosage forms, introduction to polymeric biomaterials, protein and nucleic acid-based dosage forms, and novel and targeted drug delivery systems. It highlights the physicochemical parameters used for the design, development, and evaluation of biotechnological dosage forms and describes the biological barriers to drug absorption. _x000D__x000D__x000D_Containing the right blend of mathematics, equations, diagrams, pictorials, and other pertinent information, this book provides a unified perspective that creates a greater overall understanding of basic science and cutting-edge technology._x000D_ _x000D_ Drug Development and Regulatory Process _x000D_ Introduction _x000D_ Identification of New Therapeutic Molecules _x000D_ Preclinical Research _x000D_ Formulation Development _x000D_ Regulatory Issues _x000D_ Pharmaceutical and Formulation Considerations _x000D_ Introduction _x000D_ Advantages of Pharmaceutical Dosage Forms _x000D_ Influential Factors in Dosage Form Design _x000D_ Biopharmaceutical and Physiological Considerations _x000D_ Introduction _x000D_ Drug Transport across a Polymeric Barrier _x000D_ Fick's Laws of Diffusion _x000D_ Pore Diffusion _x000D_ Matrix (Monolithic)-Type Nondegradable Device _x000D_ Biological Membranes and Drug Absorption _x000D_ Dissolution Rate and Noyes-Whitney Equation of Dissolution _x000D_ Factors Influencing Dissolution Rate _x000D_ Complexation and Protein Binding _x000D_ Introduction _x000D_ Types of Complexation _x000D_ Drug Interaction with Plasma Proteins _x000D_ Binding Equilibria _x000D_ Impact of Plasma Protein Binding on Dosing Regimens Chemical Kinetics and Stability _x000D_ Introduction _x000D_ Rates and Order of Reaction _x000D_ Factors Affecting Reaction Kinetics _x000D_ Pathways and Prevention of Chemical Decomposition of Drugs Interfacial Phenomena _x000D_ Introduction _x000D_ Liquid Interfaces _x000D_ Adsorption at Solid-Gas Interfaces _x000D_ Adsorption at Solid-Liquid Interface Rheology _x000D_ Introduction _x000D_ Newtonian Flow _x000D_ Non-Newtonian Flow _x000D_ Thixotropy Disperse System Basics _x000D_ Introduction _x000D_ Types of Colloidal Systems _x000D_ Kinetic Properties of Colloids _x000D_ Electrical Properties _x000D_ Electrostatic Effect _x000D_ Electrical Double Layer _x000D_ Stability of Colloids Surfactants and Micelles _x000D_ Introduction _x000D_ Surfactants _x000D_ HLB Systems _x000D_ Micelles _x000D_ Cloud Point _x000D_ Pharmaceutical Suspensions _x000D_ Introduction _x000D_ Classification of Suspensions _x000D_ Characteristics of Pharmaceutical Suspensions _x000D_ Formulation of Suspensions _x000D_ Flocculation and Deflocculation Pharmaceutical Emulsions _x000D_ Introduction _x000D_ Advantages of Emulsion Dosage Forms _x000D_ Types of Emulsions _x000D_ Roles of Interfacial Free Energy on Emulsification _x000D_ Formulations of Emulsions _x000D_ Emulsifying Agents Pharmaceutical Solutions _x000D_ Introduction _x000D_ pH and Solubility _x000D_ Buffer and Buffer Capacity _x000D_ Vehicles _x000D_ Types of Solutions _x000D_ Dry or Lyophilized Mixtures for Solution Tablets _x000D_ Introduction _x000D_ Types of Tablets _x000D_ Tablet Formulation _x000D_ Powder Flow and Compressibility _x000D_ Manufacturing of Tablets _x000D_ Relationship among Disintegration, Dissolution, and Absorption _x000D_ Evaluation of Tablets _x000D_ Capsules _x000D_ Introduction _x000D_ Hard Gelatin Capsules _x000D_ Soft Gelatin Capsules _x000D_ Evaluation of Capsules Injectable Dosage Forms _x000D_ Introduction _x000D_ Isotonicity.. _x000D_ Parenteral Routes of Administration _x000D_ Formulation of Parenteral Products _x000D_ Sterilization of Parenteral Products _x000D_ Types of Parenteral Dosage Forms _x000D_ Evaluation of Injectable Products _x000D_ Semisolid Dosage Forms _x000D_ Introduction _x000D_ Ointments _x000D_ Creams _x000D_ Gels _x000D_ Lotions _x000D_ Pastes _x000D_ Inserts, Implants, and Devices _x000D_ Introduction _x000D_ Inserts _x000D_ Implants _x000D_ Suppositories _x000D_ Aerosol Products _x000D_ Transdermal Patches Pharmaceutical Polymers _x000D_ Introduction _x000D_ Definitions and Architectures of Polymers _x000D_ Polymer Molecular Weight and Weight Distribution _x000D_ Biodegradablity and Biocompatibility _x000D_ Polymer Solubility _x000D_ Block Copolymers _x000D_ Intelligent or Stimuli-Sensitive Polymers _x000D_ Water-Soluble Polymers _x000D_ Bioadhesive/Mucoadhesive Polymers Drug Delivery Systems _x000D_ Introduction _x000D_ Prodrugs _x000D_ Soluble Macromolecular Carriers _x000D_ Particulate Carrier Systems _x000D_ Oral Drug Delivery _x000D_ Alternative Routes of Delivery Protein-and Peptide-Based Dosage Forms _x000D_ Introduction _x000D_ Structure of Peptides and Proteins _x000D_ Hydrophobicity of Peptides and Proteins _x000D_ Solubility of Peptides and Proteins _x000D_ Instability of Peptides and Proteins _x000D_ Formulation of Proteins and Peptides _x000D_ Antibody-Based Therapy and Delivery _x000D_ Antigenicity and Immunogenicity Biotechnology-Based Dosage Forms _x000D_ Introduction _x000D_ Genes and Gene Expression _x000D_ Gene Silencing _x000D_ Classification of Gene-Silencing Technologies _x000D_ Gene Therapy _x000D_ Each chapter contains Learning Objectives, Review Questions, and a Bibliography. _x000D_ Answers to Review Questions _x000D_ Index_x000D_