Description
Taylor & Francis Principles of Antineoplastic Drug Development and Pharmacology 1996 Edition by Richard L. Schilsky, Gerard A. Milano, Mark J. Ratain
Reviews the principles of drug development and clinical pharmacology applicable to all classes of anticancer drugs. Covers every aspect of drug development--from drug discovery to approval and routine use. Details how the successful application of pharmacological principles can improve drug delivery, individualized dosing, and the circumvention of drug resistance; elucideates proven strategies for widening the therapeutic margin between antitumor effects and severe toxicity; and more. Table of contents :- Principles of Drug DevelopmentCancer Drug Screening, Michael R. GreverThe Human Tumor-Cloning Assay, Axel-R. Hanauske, Susan G. Hilsenbeck, and Daniel D. Von HoffPhase I Clinical Trial Design, Rosemarie MickThe New Drug Approval Process: Clinical and Regulatory Aspects, Renzo CanettaDevelopment of Biological Agents, Rosemary Mazanet, Mary Ann Foote, and George MorstynPrinciples of Antineoplastic PharmacologyClinical Pharmacology of Anticancer Drugs, B. W. Berry and Charles ErlichmanPrinciples of Pharmokinetics and Pharmacodynamics, Mark J. Ratain and Rosemary MickBiochemical Modulation of Cancer Chemotherapy, George A. Sotos and Carmen J. AllegraDrug Interactions in Cancer Chemotherapy, Francois LokiecDrug-Radiation Interactions, Everett E. VokesPrinciples of Chemotherapy Interaction with Biological Agents, Mario Sznol, Christine L. Carter and Dan L. LongoHematopoietic Growth Factors and Cancer Chemotherapy, Michael S. GordonDose Intensity, William M. HryniukPrinciples of Chemotherapy Dosing Polymorphic Drug-Metabolizing Enzymes, Zhihong Lu and Robert B. DiasioHuman Cytochrome P-450, Frank J. GonzalezCellular Pharmacodynamics of Anticancer Drugs, Peter J. O'Dwyer, Thomas C. Hamilton, Kang-Shen Yao, Robert F. Ozols, and James M. GalloCancer Chemotherapy in the Elderly, Maurice SchneiderCancer Chemotherapy and Pharmacology in Children, Steven Weitman and Barton A. KamenAdaptive Control of Drug Dosage Regimens: Basic Concepts, Relevant Issues, and Clinical Applications, Roger W. JelliffeIndividualized Dosing of Anticancer Drugs, Alan V. Boddy and A. Hilary CalvertPrinciples of Drug ResistanceMultidrug Resistance, Ahmad R. SafaDNA Topoisomerases and Tumor Cell Resistance to Their Inhibitors, William T. BeckThe Glutathione System and Drug Resistance, Gerald Batist, Robyn L. Schecter, and Moulay A. Alaoui-JamaliImportance of DNA Repair in Cancer Chemotherapy, M. Eileen DolanResistance to Antimetabolites, Godefridus J. Peters and Gerrit JansenPrinciples of Drug DeliveryTargeted Drug Delivery, Pramod K. Gupta, John B. Cannon, and Anil Kumar TibrewalIntra-Arterial Chemotherapy, William D. EnsmingerIntraperitoneal Chemotherapy, Maurie MarkmanIntrathecal Chemotherapy, Susan M. Blaney and David G. PoplackSystemic Infusional Chemotherapy, Jacob J. Lokich and Norwood AndersonCircadian Pharmacodynamics, William J. M. Hrushesky, Robert de W. Marsh, and Patricia A. Wood