Description
LAP LAMBERT Academic Publishing Protivoopukholevyy Immunnyy Otvet U Bolnykh Khronicheskim Limfoleykozom 2011 Edition by Akinfieva Ol'ga
Khronicheskiy limfoleykoz (KhLL) yavlyaetsya naibolee rasprostranennym vidom leykoza sredi vsekh neoplasticheskikh zabolevaniy krovetvornoy i limfaticheskoy tkani. Izvestno, chto pri KhLL proiskhodit izmenenie funktsional'noy aktivnosti kletok, prinimayushchikh uchastie v kletochnom i gumoral'nom immunnom otvete, odnako kharakternye osobennosti immunologicheskikh narusheniy u bol'nykh KhLL v protsesse opukholevoy progressii ostayutsya do kontsa ne izuchennymi. V poslednie gody vse bol'she vnimaniya issledovateley udelyaetsya izucheniyu minornykh subpopulyatsiy immunoregulyatornykh T-limfotsitov - NKT-kletok i estestvennykh regulyatornykh T-limfotsitov (Treg-kletok), - igrayushchikh, nesmotrya na malochislennost', klyuchevuyu rol' v regulyatsii protivoopukholevogo immunnogo otveta. Razvitie vysokotekhnologichnykh immunologicheskikh metodov issledovaniya s primeneniem protochnoy lazernoy tsitofluorimetrii pozvolilo vplotnuyu podoyti k fundamental'nym aspektam otsenki roli NKT-kletok i Treg-limfotsitov v regulyatsii protivoopukholevogo immuniteta. Dannaya rabota posvyashchena ustanovleniyu roli immunoregulyatornykh T-limfotsitov i NK-kletok v patogeneze KhLL, i znachimosti ikh opredeleniya dlya prognozirovaniya techeniya zabolevaniya i otsenki effektivnosti terapii.