Description
LAP Lambert Academic Publishing Razvitie patologii pochek pri arterialnoy gipertenzii 2012 Edition by Muravlyeva Larisa, Molotov-Luchanskiy Vilen, Klyuev Dmitriy
V krovi bol'nykh glomerulopatiyami i tubulopatiyami i pri assotsiatsii s arterial'noy gipertenziey ustanovlena selektivnost' narusheniya strukturopostroeniya plazmy, mochi i lizata neytrofilov; narushenie osmoticheskoy stoykosti i rezervnogo potentsiala membran leykotsitov, eritrotsitov i trombotsitov. Opisan fenomen del'ty karbonilovykh proizvodnykh v eritrotsitakh i razvitie karbonilovogo stressa v neytrofilakh. Opredeleny trendy izmeneniya vnekletochnykh nukleinovykh kislot i intermediatov purinovogo obmena v zavisimosti ot nozologicheskoy formy khronicheskoy bolezni pochek i nalichiya arterial'noy gipertenzii, a takzhe zafiksirovano narushenie koagulyatsionnogo zvena gemostaza i izmenenie fiziko-khimicheskikh parametrov eritrotsitov. Predlozhena gipoteza, raskryvayushchaya rol' narusheniya intermediatov purinovogo obmena i vnekletochnykh nukleinovykh kislot v mekhanizmakh progressirovaniya khronicheskoy bolezni pochek. Predlozhena gipoteza, raskryvayushchaya rol' molekulyarnykh i kletochnykh narusheniy v razvitii porazheniy pochek pri arterial'noy gipertenzii. Issledovanie vypolneno pri finansovoy podderzhke Ministerstva obrazovaniya i nauki Respubliki Kazakhstan 33N. (4.2.1/33-1201)