Description
Springer Reviews And Protocols In Dt40 Research by Jean-Marie Buerstedde
The vertebrate genome DT40 has proven to be a reliable and robust research subject, with fast doubling time, easy clonability and a relatively stable karyotype. This book provides an up to date overview of the different facets of research, and also intends to help newcomers get started and avoid looming pitfalls. The collection of protocols which have been provided by a number of laboratories will be particularly useful in this regard. Cell Cycle During the Development of the Mammalian Central Nervous System.- Methodological Considerations in the Evaluation of the Cell Cycle in the Central Nervous System.- Neural Stem Cells.- Progenitors and Precursors of Neurons and Glial Cells.- Vasculogenesis and Angiogenesis.- Neuronal Migration and Malformations of Cortical Development.- Postnatal Development of Neurons and Glia.- Genome-Wide Expression Profiling of Neurogenesis in Relation to Cell Cycle Exit.- Neurogenesis and Apoptotic Cell Death.- Ion Channels and the Cell Cycle.- Nonsynaptic GABAergic Communication and Postnatal Neurogenesis.- Critical Roles of Ca2+ and K+ Homeostasis in Apoptosis.- Mammalian Neural Stem Cell Renewal.- Control of the Cell Cycle and Apoptosis in Glia.- Methods of Determining Apoptosis in Neuro-Oncology.- Cell Cycle, Neurological Disorders, and Reactive Gliosis.- Potassium Channels, Cell Cycle, and Tumorigenesis in the Central Nervous System.- Adult Neurogenesis: A Mechanism for Brain Repair?.- Enhanced Neurogenesis Following Neurological Disease.- Endothelial Injury and Cell Cycle Re-Entry.- The Contribution of Bone Marrow-Derived Cells to Cerebrovascular Formation and Integrity.- Microvessel Remodeling in Cerebral Ischemia.- Vascular and Neuronal Effects of VEGF in the Nervous System.- Epidermal Growth Factor Receptor in the Adult Brain.- Cell Cycle Re-Entry: A Mechanism of Brain Disease?.- Neurodegeneration and Loss of Cell Cycle Control in Postmitotic Neurons.- Cell Cycle Activation and the Amyloid-? Protein in Alzheimer's Disease.- Neuronal Precursor Proliferation and Epileptic Malformations of Cortical Development.- Vascular Differentiation and the Cell Cycle.- Adult Neurogenesis and Central Nervous System Cell Cycle Analysis.- Neurogenesis in Alzheimer's Disease.- The Biology of Gliomas.- p53 and Multidrug Resistance Transporters in the Central Nervous System.- Signaling Modules in Glial Tumors and Implications for Molecular Therapy.- Detection of Proliferation in Gliomas by Positron Emission Tomography Imaging.- Transformation of Normal Astrocytes Into a Tumor Phenotype.- Mechanisms of Gliomagenesis.- Future Directions.- Cell Cycle of Encapsulated Cells.- Viral Vector Delivery to Dividing Cells.- Electrical Stimulation and Angiogenesis.- Developmental and Potential Therapeutic Aspects of Mammalian Neural Stem Cells.- Mammalian Sir2 Proteins.