Description
LAP LAMBERT Academic Publishing Stressornye Izmeneniya Kharakteristik Eritrotsitov 2011 Edition by Kondrat'eva Elena, Kushnerova Natal'ya
Fiziologo-metabolicheskie kharakteristiki membran eritrotsitov yavlyayutsya tonkim pokazatelem, kharakterizuyushchim sostoyanie membran drugikh kletok organov i tkaney na urovne tselogo organizma. Interes k issledovaniyu lipidnoy sostavlyayushchey membran eritrotsitov i pokazateley ikh antioksidantnoy zashchity dlya otsenki obshchego napryazheniya pri stresse voznik posle togo, kak bylo pokazano, chto pri mnogikh stressornykh zabolevaniyakh ili boleznyakh adaptatsii narusheniya lipidnogo gomeostaza proyavlyayutsya v izmeneniyakh na urovne syvorotochnykh lipidov, a takzhe v sostoyanii protsessov lipoperoksidatsii. Vmeste s tem izucheniyu eritrotsitov kak modeli dlya issledovaniya stressornoy nagruzki na biomembrany posvyashcheny edinichnye raboty. V nastoyashchem issledovanii analiziruetsya deystvie membranopovrezhdayushchikh faktorov (vertikal'naya fiksatsiya krys za dorzal'nuyu sheynuyu skladku, intoksikatsiya chetyrekhkhloristym uglerodom krys, giperkholesterinovyy ratsion) na fiziologicheskie kharakteristiki eritrotsitov, sistemu pokazateley "perekisnoe okislenie lipidov - antioksidantnaya zashchita" i lipidnuyu sostavlyayushchuyu membran eritrotsitov, a takzhe demonstriruetsya vozmozhnost' korrektsii nablyudaemykh otkloneniy s pomoshch'yu vodno-spirtovogo ekstrakta iz laminarii yaponskoy.