Description
LAP LAMBERT Academic Publishing Syvorotochnye Markery Fibroza Miokarda Pri Arterialnoy Gipertonii 2011 Edition by Fatima Khezheva
Gipertonicheskaya bolezn' yavlyaetsya odnim iz samykh rasprostranennykh zabolevaniy i predstavlyaet ser'eznuyu sotsial'nuyu problemu. Pri etom prognoz vo mnogom opredelyaetsya stepen'yu vovlecheniya v patologicheskiy protsess serdtsa, kak "organa-misheni". Takoe porazhenie serdtsa vklyuchaet v sebya gipertrofiyu i fibroz, kotoryy morfologicheski proyavlyaetsya uvelicheniem soderzhaniya v miokarde kollagena i fibroznoy tkani. V poslednie gody dlya neinvazivnoy otsenki fibroza miokarda predlozheno izuchenie syvorotochnykh markerov sinteza i degradatsii miokardial'nogo kollagena-matriksnoy metalloproteinazy-1 (MMR-1) i tkanevogo ingibitora metalloproteinazy-1 (TIMP-1). V knige predstavlena kharakteristika markerov, rezul'taty izucheniya vzaimosvyazi ikh so strukturno-funktsional'nymi izmeneniyami serdtsa i sosudov u bol'nykh gipertonicheskoy bolezn'yu, a tak zhe dana otsenka dinamiki na fone gipotenzivnoy terapii.