Description
Humana Press Targets for Cancer Chemotherapy Transcription Factors and Other Nuclear Proteins 1st Editon 2010 Softbound by Nicholas B. La Thangue, Lasantha R. Bandara
In Targets for Cancer Chemotherapy: Transcription Factors and Other Nuclear Proteins, a panel of leading basic researchers, pharmaceutical scientists, and clinical oncologists explain in detail the therapeutically-relevant protein targets that contribute to cancer pathology and spell out their implications for cancer drug discovery and clinical application. The authors identify and illuminate selected transcription factor oncoproteins and tumor suppressors, together with nuclear proteins that are central to the phenotype of the tumor cell involved in chromatin control. The emphasis is on new targets and approaches to cancer treatment derived from the cancer cell cycle, gene control targets, and angiogenesis. Cancer Chemotherapy Based on E2F and the Retinoblastoma Pathway. Myc Oncoproteins as Targets for Therapeutic Intervention in Tumorigenesis. The AP-1 Family of Transcription Factors: Structure, Regulation, and Functional Analysis in Mice. Hypoxia-Induced Factor-1 as a Target for Anticancer Therapy. Nuclear b-Catenin Signaling as a Target for Anticancer Drug Development Histone Acetyltransferases as Potential Targets for Cancer Therapies. Histone Deacetylases. Cyclin-Dependent Kinases and Their Small-Molecule Inhibitors in Cancer Therapy. Mitogen-Activated Protein Kinase Cascades as Therapeutic Targets in Cancer. Mdm2 and ARF. The Breast Cancer Susceptibility Genes, BRCA1 and BRCA2. Human Papillomavirus Targets for Therapeutic Intervention. Apoptin as an Anticancer Therapy. E2F and Cancer Chemotherapy. Hypoxic Signaling Pathways as Targets for Anticancer Therapy. Androgen Receptor and Estrogen Receptors. Index.