Description
Springer Textbook of Personalized Medicine by Kewal K. Jain
This book is for personalized medicine as a prescription of specific treatments and therapeutics best suited for an individual and considers genetic as well as environmental factors that influence responses to therapy. Best approaches are described for integration of all available technologies for optimizing the therapy of individual patients.This comprehensive third edition covers the latest advances in personalized medicine and several chapters are devoted to various specialties, particulary cancer which is the largest area of application. The book discusses the development of personalized medicine and various players in it such as companies, academic institutions, the government, and the public as the consumer of healthcare. Additionally, the roles of bioinformatics, electronic health records, and digital technologies for personalized medicine are discussed.Textbook of Personalized Medicine, 3rd Edition serves as a convenient source of information for students at many levels and in a wide range of fields, including physicians, scientists, and decision makers in the biopharmaceutical and healthcare industries. Table of contents : - Preface to the 3rd edition1 Basic AspectsDefinition of personalized medicineHistory of medical concepts relevant to personalized medicineMolecular biological basis of personalized medicineBasics technologies for developing personalized medicine'Omics' and personalized medicineConventional medicine versus personalized medicinePersonalized medicine and evidence-based medicineRole of genetics in future approaches to healthcareRole of systems biology in personalized medicineSynthetic biology and development of personalized medicinesPersonalized digital medicineA personalized approach to environmental factors in diseaseReclassification of diseasesTranslational science and personalized medicinePersonalization of multimodal therapies2 Molecular Diagnostics in Personalized MedicineIntroductionMolecular diagnostic technologiesSequencingBiochips and microarraysSNP genotypingDetection of copy number variationsStudy of rare variants in pinpointing disease-causing genesOptical MappingProteomics in molecular diagnosisRole of nanobiotechnology in molecular diagnosticsRole of biosensors in personalized medicineGene expression profilingMolecular imaging and personalized medicineCombination of diagnostics and therapeuticsPoint-of-care diagnosisGenetic testing for disease predispositionCombination of diagnostics with therapeuticsFuture of molecular diagnostics in personalized medicine3 Role of Biomarkers in Personalized Medicine4 PharmacogeneticsBasics of pharmacogeneticsRole of molecular diagnostics in pharmacogeneticsRole of pharmacogenetics in pharmaceutical industryClinical implications of pharmacogeneticsLimitations of pharmacogeneticsPharmacoepigenomics vs pharmacogenetics in drug safetyFuture role of pharmacogenetics in personalized medicine5 PharmacogenomicsIntroductionBasics of pharmacogenomicsPharmacogenomics and drug discoveryPharmacogenomics and clinical trialsPharmacogenomic aspects of major therapeutic areasCurrent status and future prospects of pharmacogenomics6 Role of PharmacoproteomicsBasics of proteomicsProteomic approaches to the study of pathophysiology of diseasesProteomic technologies for drug discovery and developmentApplications of pharmacoproteomics in personalized medicine7 Role of Metabolomics in Personalized MedicineMetabolomics and metabonomicsMetabolomics bridges the gap between genotype and phenotypeMetabolomics, biomarkers and personalized medicineMetabolomic technologiesPharmacometabonomicsMetabonomic technologies for toxicology studiesMetabonomics/metabolomics and personalized nutritionMetabolomics for personalized medicine8 Role of Nanobiotechnology in Development of Personalized Medicine9 Personalized Biological TherapiesIntroductionRecombinant human proteinsTherapeutic monoclonal antibodiesCell therapyGene therapyPersonalized vaccinesAntisense therapy10 Personalized Non-pharmacological TherapiesIntroductionAcupuncturePersonalized hyperbaric oxygen therapyPersonalized nutritionPersonalized physical exercisePersonalized surgery11 Personalized Therapy of Cancer12 Personalized Therapy of Neurological Disorders13 Personalized Therapy of Psychiatric Disorders14 Personalized Therapy of Cardiovascular Disorders15 Personalized Therapy of Pulmonary Disorders 16 Personalized Therapy Infectious Diseases17 Personalized Approaches in Immunology18 Personalized Management of Genetic Disorders19 Personalized Management of Miscellaneous DisordersPersonalized management of DNA repair disordersPersonalized preventive medicine Personalized management of ophthalmic disorders Personalized management of skin disordersPersonalized urologyPersonalized therapy of rheumatoid arthritisPersonalized management of obesityPersonalized management of diabetesManagement of genetic disordersPersonalized management of gastrointestinal disordersPersonalized approaches to improve organ transplantationPersonalized approaches to addictionPersonalized geriatricsPersonalized pediatricsPersonalized nephrologyPersonalized gynecology20 Development of Personalized MedicineIntroductionNon-genomic factors in the development of personalized medicinePlayers in the development of personalized medicineRole of genetic banking systems and databasesRole of bioinformatics in development of personalized medicineIntegration of technologies for personalized medicineGlobal scope of personalized medicineAdvantages of personalized medicineLimitations of personalized medicineFuture of personalized medicine21 Ethical Aspects of Personalized Medicine22 Legal Aspects of Personalized Medicine23 Regulatory Aspects of Personalized MedicineFDA and personalized medicineFDA and molecular diagnostics in relation to personalized medicineRegulatory aspects of pharmacogeneticsRegulation of direct-to-consumer genetic testingFDA and pharmacogenomicsFDA and predictive medicine24 Economics of Personalized Medicine25 Future of Personalized Medicine