Description
Humana Press The Oncogenomics Handbook by William J. Larochelle, Richard A. Shimkets
An integrated overview of cancer drug discovery and development from the bench to the clinic, showing with broad strokes and representative examples the drug development process as a network of linked components leading from the discovered target to the ultimate therapeutic product. Following a systems biology approach, the authors explain genomic databases and how to discover oncological targets from them, how then to advance from the gene and transcript to the level of protein biochemistry, how next to move from the chemical realm to that of the living cell and, ultimately, pursue animal modeling and clinical development. Emerging cancer therapeutics including Ritux an, Erbitux, Gleevec Herceptin, Avastin, ABX-EGF, Velcade, Kepivance, Iressa, Tarceva, and Zevalin are addressed. Highlights include cancer genomics, pharmacogenomics, transcriptomics, gene expression analysis, proteomic and enzymatic cancer profiling technologies, and cellular and animal approaches to cancer target validation.show more Part I. Genomics, Cancer Targets, Transcriptomics, and Gene Expression AnalysisGenomic Resources for Cancer BiologistsXuefeng Bruce Ling, Gene Cutler, and Timothy HoeyCancer Drug Target Identification by SAGE, LongSAGE, and Digital KaryotypingHeiko HermekingIdentification of Novel Cancer Target Antigens Utilizing EST and Genome Sequence DatabasesTapan K. Bera, Kristi A. Egland, B. K. Lee, and Ira PastanTree-Based Cancer Classification and Diagnosis Using Gene Expression DataHeping ZhangFrom FISH to Proteomics: A Molecular Brush to Define Antitumor Drug ActionBalanehru Subramanian, Alexander Nakeff, and Frederick ValerioteGene Program Signatures for Papillomavirus E2-Mediated Senescence in Cervical Cancer Cells: Finding the Points of No ReturnSarah S. Williams, Bruce J. Aronow, and Susanne I. WellsPart II. Advances in Proteomic and Enzymatic Cancer-Profiling TechnologiesMass-Spectrometry-Based Proteomics for Cancer BiologyChen Xu and John R. Yates IIIChemical Proteomics in Drug DevelopmentDouglas A. Jeffery, Amos Baruch, and Matthew BogyoProteomics-Based Anticancer Drug DiscoveryK. K. JainCancer Metabolic Phenotype: Exploiting the Cancer Metabolome in Drug DiscoveryJohn R. Griffiths and Marion StubbsFocusing Target Discovery and Validation Through Proteogenomics and Molecular ImagingLucy A. Carver and Jan E. SchnitzerPart III. Cancer Target Validation: Cellular ApproachesRNA Interference: RNAid for Future Therapeutics?Mustapha Diallo, Katja Schmitz, and Ute SchepersImage-Based Assays of Cellular Phenotype for Drug Target Discovery and ValidationKris F. Sachsenmeier and Jonathan A. TerrettTargeting Inducible Chemotherapy Resistance Mechanisms in Colon CancerDavid Ljungman and James C. Cusack, Jr.Targeting Apoptosis Pathways for Cancer TherapyBharvin K. R. PatelPart IV. Cancer Target Validation: Animal ApproachesGenetically Engineered Mouse Models of Human Cancer for Drug Discovery and DevelopmentRonan C. O'Hagan, Min Wu, William M. Rideout III, Yinghui Zhou, and Joerg HeyerUnraveling the Complexity of Oncogenesis Through In Vivo Optical ImagingPamela Reilly ContagInnovative Strategies for Improving Engineered Mouse Models of Human Cancer for Preclinical DevelopmentJeffrey J. Martino and Suzie ChenUse of Adenovirus-Mediated Gene Transfer to Facilitate Biological Annotation of Novel GenesJeff L. Ellsworth, Andrew Feldhaus, and Steven D. HughesCancer Biology and Transgenic Technology in the Mouse: Bridging the Functional GapCindy E. McKinney and Cooduvalli S. ShashikantHomology-Based Genomic Mining of Growth Factors Implicated in Neoplasia and Nephritides: PDGF-DGary C. Starling, William J. LaRochelle, and Gulshan AraPart V. Cancer Prognostics, Diagnostics, and BiomarkersCancer Pharmacogenomics: Predicting Drug Response in the Genomic EraBrian Z. Ring and Huijun Z. RingDiagnosis and Treatment of Malignancies Using Gene Expression ProfilingJimmy C. Sung, Alice Y. Lee, and Timothy J. YeatmanImplications of Epigenetics for Early Cancer Diagnosis and PreventionMukesh Verma and Sudhir SrivastavaNovel Molecular and Genetic Prognostic Biomarkers in Prostate CancerArnab Chakravarti and Gary Guotang ZhaiPSA in Prostate Cancer DiagnosisPradip DattaTumor Targets and Biomarkers in Renal Cell CarcinomaIvar Bleumer and Peter F. A. MuldersPart VI. Emerging Approaches to Cancer TherapyVI-A. Targeting the VasculatureTumor Vasculature as a Target for Cancer TherapyGrzegorz