Description
Humana Tumor Suppressor Genes Volume 1 Pathways And Isolation Strategies by Wafik S. El-Deiry
It has become clear that tumors arise from excessive cell proliferation and a c- responding reduction in cell death. Tumors result from the successive accumulation of mutations in key regulatory target genes over time. During the 1980s, a number of oncogenes were characterized, whereas from the 1990s to the present, the emphasis shifted to tumor suppressor genes (TSGs). It has become clear that oncogenes and tumor suppressor genes function in the same pathways, providing positive and ne- tive growth regulatory activities. The signaling pathways controlled by these genes involve virtually every process in cell biology, including nuclear events, cell cycle, cell death, cytoskeletal, cell membrane, angiogenesis, and cell adhesion effects. Tumor suppressor genes are mutated in hereditary cancer syndromes, as well as somatically in nonhereditary cancers. In their normal state, TSGs control cancer development and p- gression, as well as contribute to the sensitivity of cancers to a variety of therapeutics. Understanding the classes of TSGs, the biochemical pathways they function in, and how they are regulated provides an essential lesson in cancer biology. We cannot hope to advance our current knowledge and to develop new and more effective therapies without understanding the relevant pathways and how they influence the present approaches to therapy. Moreover, it is important to be able to access the powerful tools now available to discover these genes, as well as their links to cell biology and growth control. Part I. Known Tumor Suppressor Genes and PathwaysGrowth Control by the Retinoblastoma Gene FamilyMarco G. Paggi, Armando Felsani, and Antonio GiordanoThe APC Tumor Suppressor PathwayPatrice J. Morin and Ashani T. WeeraratnaHereditary Breast and Ovarian Cancer GenesRalph Scully and Nadine PugetHereditary Colon Cancer GenesWilliam M. Grady and Sanford D. MarkowitzPatched, Hedgehog, and Skin CancerAnthony G. Quinn and Ervin Epstein, Jr.Tumor Suppressor Genes in Lung CancerArvind K. Virmani and Adi F. GazdaTP53, hChk2, and the Li-Fraumeni SyndromeJenny VarleyGenetic Alterations in Esophageal CancerJun-ichi Okano, Lorraine Snyder, and Anil K. RustgiPTEN and CancerRamon Parsons and Laura SimpsonVHL and Kidney CancerMichael Ohh and William G. Kaelin, Jr.p16INK4A and Familial MelanomaKapaettu Satyamoorthy and Meenhard HerlynThe INK4a/ARF Locus and Human CancerGreg H. EndersProgression Model of Prostate CancerTeresa Acosta Almeida and Nickolas PapadopoulosNeurofibromatosis Type 1Margaret E. McLaughlin and Tyler JacksWilms' Tumor as a Model for Cancer BiologyAndrew P. Feinberg and Bryan R. G. WilliamsInadequate 'Caretaker' Gene Function and Human Cancer DevelopmentTheodore L. DeWeese and William G. NelsonRegulation of Tumor Suppressor Genes by OncogenesPaul Dent, Liang Qiao, Donna Gilfor, Michael Birrer, Steven Grant, and Paul B. FisherPart II. Identification of Tumor Suppressor GenesDetermination of Cancer AllelotypeJennifer J. Ascano and Steven M. PowellEpidemiologic Approaches to the Identification of Cancer Predisposition GenesTimothy R. RebbeckCharacterization of Translocations in Human CancerKeri Fairand Michelle M. Le BeauPositional Approaches to Cancer GeneticsGavin P. Robertson, Linda Sargent, and Mark A. NelsonHybrid Capture of Putative Tumor Suppressor GenesBryan L. Betz and Bernard E. WeissmanApproaches to Proteomic Analysis of Human TumorsMamoun Ahram and Michael R. Emmert-BuckRepresentational Difference Analysis of Gene ExpressionJames M. Bugni and Norman R. DrinkwaterAntisense Libraries to Isolate Tumor Suppressor GenesAdi KimchiGenetic Suppressor Elements in the Characterization and Identification of Tumor Suppressor GenesIgor B. Roninson and Andrei V. GudkovCross-linking Subtractive Hybridization to Identify Tumor Suppressor GenesGen Sheng WuSuppression Subtractive Hybridization for Identification and Functional Analysis of Tumor Suppressor GenesIuri D. Louro, Evans C. Bailey, and J. Michael RuppertSAGE as a Strategy to Isolate Cancer-Related GenesKathy Boon and Gregory J. RigginsDifferential Display Techniques to Identify Tumor Suppressor Gene PathwaysSiham Biade and Maureen E. MurphyDetection of Mismatch Repair Gene Expression in Urologic MalignanciesFredrick S. LeachIndex