Description
Elsevier Handbooks In Operations Research And Management Science Simulation Volume 13 by Shane G. Henderson
This Handbook is a collection of chapters on key issues in the design and analysis of computer simulation experiments on models of stochastic systems. The chapters are tightly focused and written by experts in each area. For the purpose of this volume "simulation" refers to the analysis of stochastic processes through the generation of sample paths (realization) of the processes. Attention focuses on design and analysis issues and the goal of this volume is to survey the concepts, principles, tools and techniques that underlie the theory and practice of stochastic simulation design and analysis. Emphasis is placed on the ideas and methods that are likely to remain an intrinsic part of the foundation of the field for the foreseeable future. The chapters provide up-to-date references for both the simulation researcher and the advanced simulation user, but they do not constitute an introductory level 'how to' guide. Computer scientists, financial analysts, industrial engineers, management scientists, operations researchers and many other professionals use stochastic simulation to design, understand and improve communications, financial, manufacturing, logistics, and service systems. A theme that runs throughout these diverse applications is the need to evaluate system performance in the face of uncertainty, including uncertainty in user load, interest rates, demand for product, availability of goods, cost of transportation and equipment failures. Preface. Introduction. List of Contributors. Abbreviations. PART I: GENERAL ASPECTS OF ANALOGUE-BASED DRUG DISCOVERY. 1. Analogues as a Means of Discovering New Drugs. 2. Drug Likeness and Analogue-Based Drug Discovery. 3. Privileged Structures and Analog-Based Drug Discovery. PART II: SELECTED EXAMPLES FROM THE ANALOGUE-BASED DRUG DISCOVERIES. 1. Development of Anti-Ulcer H2-Receptor Histamine Antagonists. 2. Esomeprazole in the Framework of Proton-Pump Inhibitor Development. 3. The Development of a New Proton-Pump Inhibitor: The Case History of Pantoprazole. 4. Optimizing the Clinical Pharmacologic Properties of the HMG-CoA Reductase Inhibitors. 5. Optimizing Antihypertensive Therapy by Angiotensin Receptor Blockers. 6. Optimizing Antihypertensive Therapy by Angiotensin-Converting Enzyme Inhibitors. 7. Case Study of Lacidipine in the Research of New Calcium Antagonists. 8. Selective Beta-Adrenergic Receptor-Blocking Agents. 9. Case Study: "Esmolol Stat". 10. Development of Organic Nitrates for Coronary Heart Disease. 11. Development of Opioid Receptor Ligands. 12. Stigmines. 13. Structural Analogues of Clozapine. 14. Quinolone Antibiotics: The Development of Moxifloxacin. 15. The Development of Bisphosphonates as Drugs. 16. Cisplatin and its Analogs for Cancer Chemotherapy. 17. The History of Drospirenone. 18. Histamine H1 Blockers: From Relative Failures to Blockbusters Within Series of Analogues. 19. Corticosteroids: From Natural Products to Useful Analogues. PART III: TABLE OF SELECTED ANALOGUE CLASSES. Index.