Description
Springer Physiology of the Fetal and Neonatal Lung 1985 1st Editon 2012 Softbound by D.V. Walters, L.B. Strang, F. Geubelle
L. B. STRANG The past 25 years have seen a remarkable growth in our knowledge of lung development in its structural, physiological and biochemical dimensions. Much of the impetus for research leading to new knowledge has derived from the perception that many respiratory disorders in the newborn infant are due to defective development or maladaption of some component or components of the respiratory system. Thus, to cite one example, surfac tant deficiency is clearly seen to be the cause of atelectasis in hyaline mem brane disease; and to cite another, it is widely accepted that the mechanisms controlling patency of the ductus arteriosus and pulmonary vascular resistance also determine the right-to-Ieft or left-to-right shunting frequently observed in the course of neonatal respiratory disorders. There are, however, areas of physiological knowledge - such as those relating to respiratory control and to liquid formation and absorption - which are clearly of great relevance to lung adaptation at birth but where it has not yet proved possible to link a specific clinical state to the malfunction of a particular mechanism. In planning this symposium an attempt was made to organize the material in an orderly manner, starting with the embryonic and fetal stages of growth and development, continuing with respiratory control and the role of surfactant in lung aeration at birth, and ending with the treatment of neonatal respiratory disorders. 1. Lung embryogenesis and differentiation.- Discussion.- 2. Differentiation of the pulmonary epithelium.- Discussion.- 3. Factors affecting fetal lung growth.- Discussion.- 4. Postnatal lung development and modulation of lung growth.- Discussion.- 5. The secretion and absorption of fetal lung liquid.- Discussion.- 6. Development of epithelial ion transport in fetal and neonatal airways.- Discussion.- 7. Analysis of ion and fluid transport across a vertebrate pulmonary epithelium studied in vitro.- Discussion.- 8. The maturation of the control of respiration in infancy.- Discussion.- 9. Establishment of the end-expiratory level (FRC) in newborn mammals.- Discussion.- 10. Postnatal development of lung function.- 11. Alveolar ventilation in newborns and its post-natal development.- Discussion.- 12. Some relationships among structure, composition, and functional characteristics of lung surfactant.- Discussion.- 13. Aspects of surfactant metabolism in the adult and perinatal lung.- Discussion.- 14. myo-Inositol and perinatal development of surfactant.- Discussion.- 15. Absorption of fetal lung liquid and exogenous surfactant in premature lambs.- Discussion.- 16. Surfactant inhibitory plasma-derived proteins.- Discussion.- 17. Surfactant replacement: theory and practice.- Discussion.- 18. The Cambridge experience of artificial surfactant.- Discussion.- 19. Surfactant supplementation: Toronto trial.- Discussion.- 20. Mechanical ventilation: the role of high-frequency ventilation.- Discussion.