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Springer The Herpesviruses Immunobiology and Prophylaxis of Human Herpesvirus Infections 1st Editon 2012 Softbound by Carlos Lopez, Bernard Roizman
'You damn sadist/said mr cummings 'you try to make people think. ' -Ezra Pound (Canto 89) What makes herpesviruses unique? It is certainly not the size of their genomes or the individual features of their reproductive cycle, although in toto striking features that are exclusive to the herpesviruses abound. Unquestionably, the pre-eminent feature is the relationship of herpes viruses with their natural hosts. As described in preceding volumes, all herpesviruses seem to be able to colonize and to remain in a latent, nonproductive form for life of their hosts. Once established in the host, the relationship is best described as that of an armed truce. What happens when this truce breaks down or when the host encounters the virus for the first time is the subject of this volume. We have focused primarily on the five human herpesviruses [herpes simplex virus 1 (HSV-l), herpes simplex virus 2 (HSV-2), cytomegalovirus (CMV), varicella zoster virus (VZV) and Epstein-Barr virus (EBV)] because much more is known about them than about any other herpesviruses, and because it is of interest to compare both the diversity of manifestations of infections with human herpesviruses and the spectrum of human responses to these viruses. This volume summarizes the current knowledge of the pathogenesis and immunobiology of herpesvirus infections in man and describes new and developing approaches to prophylaxis and treatment. It contains con tributions from distinguished research scientists presently engaged at the forefront of these scientific investigations. 1 The Natural History of Genital Herpes Simplex Virus: Perspectives on an Increasing Problem.- 2 Natural Resistance Mechanisms in Herpes Simplex Virus Infections.- 3 Humoral Response to Herpes Simplex Virus Infections.- 4 The T-Cell-Mediated Immune Response of Mice to Herpes Simplex Virus.- 5 Immunopathology of Herpesvirus Infections.- 6 Cell-Mediated Immunity in Cytomegalovirus Infections.- 7 In Vivo Studies of Epstein-Barr Virus and Other Lymphotropic Herpesviruses of Primates.- 8 Cell-Mediated Immunity to EBV.- 9 Immunobiology of EBV-Associated Cancers.- 10 Cytomegalovirus Infection after Organ Allografting: Prospects for Immunoprophylaxis.- 11 Epstein-Barr Virus and the X-Linked Lymphoproliferative Syndrome.- 12 Abnormal Responses to EBV Infection in Patients with Impairment of the Interferon System.- 13 Vaccination against Herpes Simplex Virus Infections.- 14 CMV Vaccines.- 15 Live Attenuated Varicella Vaccine.- 16 A Subunit Vaccine against Epstein-Barr Virus.- 17 A Perspective on the Therapy of Human Herpesvirus Infections.- 18 The Role of Interferon in Immunity and Prophylaxis.- 19 Effects of Immunopotentiating and Immunomodulating Agents on Experimental and Clinical Herpesvirus Infections.