Statistics Applied To Clinical Trials 4th Edition at Meripustak

Statistics Applied To Clinical Trials 4th Edition

Books from same Author: CLEOPHAS T J

Books from same Publisher: SPRINGER

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  • General Information  
    Author(s)CLEOPHAS T J
    PublisherSPRINGER
    Edition4th Edition
    ISBN9781402095221
    Pages584
    BindingHardbound
    LanguageEnglish
    Publish YearMarch 2009

    Description

    SPRINGER Statistics Applied To Clinical Trials 4th Edition by CLEOPHAS T J

    The previous three editions of this book, rather than having been comprehensive, concentrated on the most relevant aspects of statistical analysis. Although well-received by students, clinicians, and researchers, these editions did not answer all of their questions. This updated and extended edition has been written to serve as a more complete guide and reference-text to students, physicians, and investigators, and, at the same time, preserves the common sense approach to statistical problem-solving of the previous editions. In 1948 the first randomized controlled trial was published by the English Medical Research Council in the British Medical Journal. Until then, observations had been uncontrolled. Initially, trials frequently did not confirm hypotheses to be tested. This phenomenon was attributed to little sensitivity due to small samples, as well as inappropriate hypotheses based on biased prior trials. Additional flaws were being recognized and, subsequently were better accounted for: carryover effects due to insufficient washout from previous treatments, time effects due to external factors and the natural history of the condition under study, bias due to asymmetry between treatment groups, lack of sensitivity due to a negative correlation between treatment r...